清末民初,佛山武学宗师黄飞鸿因噩梦预感女记(jì )者(zhě )莫(mò )十(shí )三(sān )遇险,携弟子前往古云村寻人。村中蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿(hóng )闯(chuǎng )祭(jì )坛(tán )救(jiù )人(rén ),因(yīn )不(bú )忍(rěn )伤(shāng )及(jí )被(bèi )蛊(gǔ )惑的村民反中蛊毒,幸得卧底蜈蚣教的鬼脚七暗中相助。众人合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄(huáng )飞(fēi )鸿(hóng )潜(qián )入(rù )会(huì )馆救出被掳孩童,对决主事服部一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性(xìng )命(mìng )相(xiàng )要(yào )挟(jiā )。黄(huáng )飞(fēi )鸿(hóng )于(yú )绝(jué )境(jìng )中(zhōng )融(róng )合腿法,悟出佛山无影脚,击杀麦克罗。蛊毒尽解,百姓恢复神智,广州重归太平,宝芝林重回烟火日常。